99255-43-3Relevant academic research and scientific papers
PREVENTIVES/REMEDIES FOR ORGAN FUNCTIONAL DISORDERS AND ORGAN DYSFUNCTION
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Page/Page column 38, (2010/02/06)
The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compou
Benzoxazepinones and their use as squalene synthase inhibitors
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, (2008/06/13)
There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.
Methods for the treatment of hypertension
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, (2008/06/13)
Acetylene compounds of the formula (I): STR1 wherein Y, R1, R2, R3, and R4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The compounds possess antihyperte
Acetylene amines and their use as vasodilators and antihypertensives
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, (2008/06/13)
Acetylenes of the following formula (I): STR1 wherein Y, m, R1, R2, R3, n and R4 are defined herein and R5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators and antihypertens
Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
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, (2008/06/13)
Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.
