99272-76-1

Basic information

• Product Name: 4-{(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester
• Synonyms: 4-{(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester
• CAS NO: 99272-76-1
• Molecular Weight: 956.343
• Mol File: 99272-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester(99272-76-1)
• EPA Substance Registry System: 4-{(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-hydroxymethyl-tetrahydro-furan-3-yloxy}-4-methoxy-heptanedioic acid dimethyl ester(99272-76-1)

Safety Data

• Hazardous Substances Data: 99272-76-1(Hazardous Substances Data)

Upstream product

• 99272-60-3 2'-O-(3-methoxy-1,5-dicarbomethoxypentanyl)-5'-O-(9-phenylxanthen-9-yl)-6-N-benzoyladenosine 
• 99272-67-0 triethylammonium salt of 2'-O-(3-methoxy-1,5-dicarbomethoxypentanyl)-5'-O-pixyl-3'-O-(o-chlorophenyl)-phosphate-6-N-benzoyladenosine 
• 72351-28-1 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) 
• 24324-17-2 9-Fluorenylmethanol 
• 99272-72-7 4-[(2R,3R,4R,5R)-2-(6-Benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-(9H-fluoren-9-ylmethoxy)-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester 

Relevant articles and documents

Chemical synthesis of a pentaribonucleoside tetraphosphate constituting the 3'-acceptor stem sequence of E. coli tRNAIle using 2'-O-(3-methoxy-1,5-dicarbomethoxypentan-3-yl)-ribonucleoside building blocks. Application of a new achiral and acid-labile 2'-hydroxyl protecting group in tRNA synthesis.

A synthesis of a pentaribonucleotide fragment constituting the residues 59-63 of 3'-terminus of E. coli tRNAIle, 5'-ApGpUpCpC-3', has been carried out using a new, easily accessible and achiral 2'-ketal protecting group. The new 2'-ketal group has an additional advantage in that it is easily functionalized to the diamide with aqueous ammonia in the penultimate step of deblocking of fully protected oligoribonucleotides. Such a functionalization of the 2'-ketal group at the penultimate step of deblocking of the fully protected tRNA molecule enhances its relative rate of removal under an acidic condition with a minimum of damage of the target tRNA molecule.