Human Neutrophil Peptide-2 (HNP-2), also known as defensin-2, is a small cationic peptide produced by neutrophils, a type of white blood cell. It plays a crucial role in the immune system as a natural antimicrobial peptide, with the ability to disrupt the membranes of various pathogens, including bacteria, fungi, and viruses. HNP-2 is also involved in the regulation of inflammation and immune response, making it a key component in the body's defense against infectious agents. Additionally, it has been studied for its potential therapeutic applications in the treatment of various infectious and inflammatory diseases.
99287-07-7
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Basic information
- Product Name: HUMAN NEUTROPHIL PEPTIDE-2
- Synonyms: DEFENSIN 2 (HUMAN);DEFENSIN HNP-2 (HUMAN);DEFENSIN (HUMAN) HNP-2;DEFENSIN HUMAN NEUTROPHIL PEPTIDE-2;CYCRIPACIAGERRYGTCIYQGRLWAFCC (DISULFIDE BRIDGE: 1-29,3-18,8-28);HUMAN NEUTROPHIL PEPTIDE-2;HNP-2;H-CYS-TYR-CYS-ARG-ILE-PRO-ALA-CYS-ILE-ALA-GLY-GLU-ARG-ARG-TYR-GLY-THR-CYS-ILE-TYR-GLN-GLY-ARG-LEU-TRP-ALA-PHE-CYS-CYS-OH
- CAS NO:99287-07-7
- Molecular Formula: C147H217N43O37S6
- Molecular Weight: 3370.95
- EINECS: N/A
- Product Categories: peptide
- Mol File: 99287-07-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 1.50±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: HUMAN NEUTROPHIL PEPTIDE-2(CAS DataBase Reference)
- NIST Chemistry Reference: HUMAN NEUTROPHIL PEPTIDE-2(99287-07-7)
- EPA Substance Registry System: HUMAN NEUTROPHIL PEPTIDE-2(99287-07-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 99287-07-7(Hazardous Substances Data)
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99287-07-7 Usage
Uses
Used in Pharmaceutical Industry:HNP-2 is used as an antimicrobial agent for its ability to disrupt the membranes of various pathogens, including bacteria, fungi, and viruses. This makes it a potential candidate for the development of new antibiotics and antifungal drugs to combat drug-resistant infections.
Used in Immunology Research:
HNP-2 is used as a research tool for studying the immune system and its role in the regulation of inflammation and immune response. This helps scientists better understand the body's defense mechanisms against infectious agents and develop new therapeutic strategies.
Used in Therapeutic Applications:
HNP-2 is used as a potential therapeutic agent for the treatment of various infectious and inflammatory diseases. Its antimicrobial and immunomodulatory properties make it a promising candidate for the development of new treatments for conditions such as sepsis, pneumonia, and chronic inflammatory disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 99287-07-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,2,8 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.Calculate Digit Verification of CAS Registry Number 99287-07:
(7*9)+(6*9)+(5*2)+(4*8)+(3*7)+(2*0)+(1*7)=187
187 % 10 = 7
So 99287-07-7 is a valid CAS Registry Number.
99287-07-7Upstream product
99287-07-7Downstream Products
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HUMAN NEUTROPHIL PEPTIDE-2
