99298-05-2

Basic information

• Product Name: 2-Pentenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-phenyl-, methyl ester, (2E,4S)-
• CAS NO: 99298-05-2
• Molecular Formula: C17H23NO4
• Molecular Weight: 305.374
• Mol File: 99298-05-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Pentenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-phenyl-, methyl ester, (2E,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-phenyl-, methyl ester, (2E,4S)-(99298-05-2)
• EPA Substance Registry System: 2-Pentenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-phenyl-, methyl ester, (2E,4S)-(99298-05-2)

Safety Data

• Hazardous Substances Data: 99298-05-2(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 72155-45-4 Boc-L-phenylalaninal 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 99281-72-8 (E)-(S)-4-Amino-5-phenyl-pent-2-enoic acid methyl ester 
• 139545-04-3 [L-(trans)]-4-[(t-butoxycarbonyl)amino]-5-phenyl-2-pentenoic acid 
• 851967-47-0 (E)-(S)-4-(3-biphenyl-4-yl-ureido)-5-phenyl-pent-2-enoic acid methyl ester 
• 142723-72-6 (E)-(S)-4-((E)-(S)-4-tert-Butoxycarbonylamino-5-phenyl-pent-2-enoylamino)-5-phenyl-pent-2-enoic acid methyl ester 
• 213126-01-3 (E)-(S)-4-[3-(2-Iodo-phenyl)-ureido]-5-phenyl-pent-2-enoic acid methyl ester 
• 299182-18-6 tert-butyl (1S)-5-diazo-1-benzyl-4-oxopentylcarbamate 
• 195867-20-0 (4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpentanoic acid 
• 724784-49-0 methyl (4R)-4-[(2-hydroxypentadecanoyl)amino]-5-phenylpentanoate 
• 724784-48-9 methyl (4R)-4-[(2-hydroxyoctanoyl)amino]-5-phenylpentanoate 
• 760214-71-9 {3-[(E)-(S)-4-(3-biphenyl-4-yl-ureido)-5-phenyl-pent-2-enoylamino]-propyl}-carbamic acid tert-butyl ester 
• 760214-63-9 (2-{(E)-(S)-4-[3-(4-phenoxy-phenyl)-ureido]-5-phenyl-pent-2-enoylamino}-ethyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus

Emerging infectious diseases like those caused by arboviruses such as Venezuelan equine encephalitis virus (VEEV) pose a serious threat to public health systems. Development of medical countermeasures against emerging infectious diseases are of utmost importance. In this work, an acrylate and vinyl sulfone-based chemical series was investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's nonstructural protein 2 (nsP2). Primary screen and dose response studies were performed to evaluate the potency and cytotoxicity of the compounds. The results provide structural insights into a new class of potent nonpeptidic covalent inhibitors of nsP2 cysteine protease represented by compound 11 (VEEV TrD, EC50= 2.4 μM (HeLa), 1.6 μM (Vero E6)). These results may facilitate the evolution of the compounds into selective and broad-spectrum anti-alphaviral drug leads.

GLYT2 MODULATORS

α-, β-, and γ-amino acid derivatives of formula I are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. Formula I

Intramolecular nucleophilic epoxidation of γ-amino-α,β- unsaturated esters with an N-hydroperoxymethyl group

Intramolecular nucleophilic epoxidation reactions of γ-amino-α, β-unsaturated esters have been studied for the first time with a hydroperoxymethyl group attached to the nitrogen atom. The epoxidation was fast under mild basic conditions and highly anti se