99314-92-8

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 56291-51-1 2-amino-3-methylaminopyridine 
• 99314-95-1 N³-benzyloxycarbonyl-N²-methoxycarbonyl-2,3-diaminopyridine 
• 1415570-55-6 methyl 8-(((benzyloxy)carbonyl)amino)-2-(2-(bis(tertbutoxycarbonyl)amino)ethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1415570-54-5 ethyl 8-(((benzyloxy)carbonyl)amino)-2-(4-(methoxymethoxy)phenyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1415570-53-4 methyl 8-(((benzyloxy)carbonyl)amino)-2-(((4-methoxybenzyl)oxy)methyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1415570-52-3 methyl 8-(((benzyloxy)carbonyl)amino)-2-(but-3-en-1-yl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1415570-51-2 ethyl 8-(((benzyloxy)carbonyl)amino)-2-phenylimidazo[1,2-a]pyridine-3-carboxylate 
• 1415570-50-1 methyl 8-(((benzyloxy)carbonyl)amino)-2-methylimidazo[1,2-a]pyridine-3-carboxylate 
• 32282-07-8 N²-benzyl-2,3-pyridinediamine 
• 99315-03-4 N²-Benzyl-N³-methyl-pyridine-2,3-diamine 
• 69634-21-5 N-(3-aminopyridin-2-yl)benzamide 
• 32282-06-7 3-amino-2-(ethylamino)pyridine 
• 5028-20-6 3-amino-2-methylaminopyridine 
• 99314-94-0 (2-Benzoylamino-pyridin-3-yl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

HIV INTEGRASE INHIBITORS

Pyridopyrimidine carboxamide compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein R1, R2, R3, R4, R5 and R6 are defined herein. The compounds ar

Synthesis and mutagenic potency of structural isomers of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

(Chemical Equation Presented) Synthesis of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP), three structural isomers, and two desphenyl PhIP congeners has been carried out. Mutagenic potency was evaluated using S. typhimurium strain TA98 in the Ames test. Mutagenic potency increased in relation to structural features in these heterocyclic amines that allow extended resonance between the phenyl and imidazo[4,5-b]pyridine N2-amino substituents. By contrast, PhIP isomers, whose substitution disallows involvement of the phenyl group in their ammoimidazo resonance hybrids, and desphenyl congeners were from 86- to 234-fold less mutagenic than PhIP.

3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors

An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate is described. The scope of the synthesis regarding the introduction of substituents on the pyrido-fused ring is explored.

HIV INTEGRASE INHIBITORS

Pyridopyrimidine carboxamide compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: Formula (I); wherein R1, R2, R3, R4, R5 and R6 are defined herein. The