99315-36-3

Upstream product

• 62-53-3 aniline 
• 13104-53-5 4-chloro-3,3-dimethylbutane-2-one 
• 106367-28-6 [3-Chloro-1,2,2-trimethyl-prop-(E)-ylidene]-phenyl-amine 
• 99315-30-7 2,3,3-Trimethyl-1-phenyl-azetidine-2-carbonitrile 

Relevant academic research and scientific papers

SYNTHESIS OF AZETIDINES FROM β-CHLORO IMINES

The reaction of β-chloro imines 4 with potassium cyanide in methanol or with lithium aluminium hydride in dry ether gave rise to 2-cyanoazetidines 5 and azetidines 21.The reaction proceeded by nucleophilic addition of cyanide or hydride across the carbon-

A Novel Synthesis of 2-Cyano-3,3-dimethylazetidines

A new route to 2-cyano-3,3-dimethylazetidines has been developed by reaction of β-chloroimines with potassium cyanide in methanol which involves nucleophilic addition and subsequent intramolecular nucleophilic substitution.