99323-00-9

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 108-46-3 recorcinol 
• 541-47-9 3-Methylbutenoic acid 

Downstream Products

• 17771-33-4 7-hydroxy-2,2-dimethyl-chroman-4-one 
• 17598-02-6 2,2 dimethyl 7 methoxychromene 
• 59257-86-2 7-(benzyloxy)-2,2-dimethylchroman-4-one 
• 115613-80-4 2,2-Dimethyl-7-propoxy-chroman-4-one 
• 67147-67-5 7-Ethoxy-2,2-dimethyl-2H-chromene 
• 75587-02-9 7-Isopropoxy-2,2-dimethyl-2H-chromene 
• 70442-01-2 2,2-Dimethyl-7-prop-2-ynyloxy-2H-chromene 
• 94243-84-2 7-Cyclohexyloxy-2,2-dimethyl-2H-chromene 
• 120046-19-7 7-Cyclohexyloxy-2,2-dimethyl-chroman-4-one 
• 94243-90-0 7-(benzyloxy)-2,2-dimethyl-2H-1-benzopyran 
• 120046-35-7 7-Cyclohexyloxy-2,2-dimethyl-chroman-4-ol 
• 120065-27-2 7-(4-Chloro-benzyloxy)-2,2-dimethyl-2H-chromene 
• 120046-23-3 7-((4-chlorobenzyl) oxy)-2,2-dimethylchroman-4-one 
• 120046-26-6 7-(2-Chloro-benzyloxy)-2,2-dimethyl-2H-chromene 

Relevant academic research and scientific papers

ON THE REACTION OF SUBSTITUTED PHENOLS AND 3-METHYLBUT-2-ENOIC ACID. A COMPARATIVE STUDY

A systematic and comparative study of the reaction of a series of substituted phenols and 3-methylbut-2-enoic acid in zinc chloride/phosphorus oxychloride and aluminum chloride/phosphorus oxychloride reveals that the formation of phenolic esters and 2,2-dimethyl-4-chromanones is strongly influenced by the substituents, their popsition on the aromatic ring of the starting phenols.Based on our study, a mixed Friedel-Crafts and Fries rearrangement mechanism is in operation in these reactions.

On the synthesis of substituted 2,2-dimethyl1-4-chromanones and related compounds

A systematic study of the reaction of a series of monosubstituted phenols 3 and 3-methylbut-2-enoic acid 4 in phosphorus oxychloride/zinc chloride revealed that the formation of 4-chromanones was strongly infuenced by the substituents and their position on the aromatic ring of the starting phenols.

Synthesis of 1-aryl-3-methyl-but-2-en-1-ones intermediates for the synthesis of chromanone derivatives

A convenient preparation of hitherto unknown compounds 3a, 4a, 3c, 4b and 4c by Friedel-Crafts reaction of active phenol derivatives and 3,3-dimethylacrylol chloride using anhydrous aluminium iodide as the condensing agent is described.