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Intramolecular Nucleophilic Catalysis of Anilide Hydrolysis by Pyrimidine Nitrogen
Blagoeva, Iva B.,Kirby, Anthony J.
, p. 1017 - 1020 (2007/10/02)
The neighbouring pyrimidine group of the conjugate acid of 2-(4-aminopyrimidin-2-ylthio)-2-methyl-p-nitropropananilide (3) is an effective nucleophilic catalyst for the hydrolysis of the p-nitroanilide function.The reactivity of pyrimidine nitrogen parall
