99328-40-2Relevant academic research and scientific papers
The Sense of Asymmetric Induction on Addition to α-Chiral Aldehydes
Hoffmann, Reinhard W.,Weidmann, Ulrich
, p. 3966 - 3979 (2007/10/02)
On addition of (E)-crotylboronates to aldehydes with an α-methyl branch the expected Cram-products are formed predominantly.On addition of the (Z)-crotylboronates to the same aldehydes the anti-Cram-products are formed in preference.Hence, the sense of 1,2-asymmetric induction depends also on the nature of the achiral reagent.The reasons for and the conditions leading to such a phenomenon are discussed.
