99329-70-1

Usage

Uses

Used in Pharmaceutical Research and Development:
4-(3-Chlorophenyl)piperidine hydrochloride is used as a research chemical for the development of new drugs, particularly those targeting dopamine receptors. Its interaction with these receptors makes it a valuable compound in the study and treatment of neurological and psychiatric disorders.
Used in Neurological and Psychiatric Disorders Treatment:
In the field of neurology and psychiatry, 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE is used as a therapeutic agent for its potential effects on various disorders. Its modulation of dopamine receptors could contribute to the management of conditions such as schizophrenia, Parkinson's disease, and addiction.
Used in Drug Addiction Treatment:
4-(3-Chlorophenyl)piperidine hydrochloride is used as a potential treatment for drug addiction and related disorders. Its influence on dopamine pathways, which are often implicated in addiction, positions it as a candidate for further research and development in addiction medicine.
Used in Chemical Synthesis:
In the chemical synthesis industry, 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE is used as a building block for the creation of other pharmaceuticals and research chemicals. Its structural properties allow it to be a versatile component in the synthesis of a range of compounds with diverse applications.

InChI:InChI=1/C11H14ClN.ClH/c12-11-3-1-2-10(8-11)9-4-6-13-7-5-9;/h1-3,8-9,13H,4-7H2;1H

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 99329-63-2 1-benzyl-4-(3-chlorophenyl)-1,2,3,6-tetrahydropyridine 
• 99329-66-5 1-benzyl-4-(3-chlorophenyl)piperidin-4-ol 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 764634-69-7 4-(3-chlorophenyl)-1-methylpiperidine 

Relevant academic research and scientific papers

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

Synthesis of piperidine analogs of 1-(3- chlorophenyl)piperazine, a well known serotonin ligand

Synthesis of arylpiperideines 3a-3d and arylpiperidines 4a- 4d as analogs of a well known serotonin ligand 1-(3- chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1-methyl-piperdin-4-one to provide the corresponding hydroxy derivatives 6a and 6b. N- Methylpiperideine derivatives 3a and 3c were obtained by their dehydration while the corresponding N-unsubstituted compounds 3b and 3d were prepared indirectly by a three-step procedure. Hydrogenation of piperideine 3a provided the corresponding piperidine derivative 4a which after demethylation yielded 4b. Similar 4-pyridyl derivatives 4c and 4d were prepared by a similar strategy via the corresponding methoxy derivatives.