99334-37-9

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 2-mercapto-5-nitro-, is used as an antibacterial and antifungal agent for its ability to combat various microbial infections. Its presence in pharmaceutical formulations helps in maintaining the sterility and shelf life of the products.
Used in Organic Synthesis:
In the field of organic synthesis, Benzoic acid, 2-mercapto-5-nitro-, serves as a key intermediate in the production of various organic compounds. Its unique functional groups facilitate a range of chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used as a Research Reagent:
Benzoic acid, 2-mercapto-5-nitro-, is utilized as a research reagent in biochemical and pharmaceutical research. Its distinctive chemical structure allows scientists to explore its interactions with biological systems, potentially leading to the discovery of new therapeutic agents and understanding of biological processes.
Used in Food Preservation:
As a derivative of benzoic acid, Benzoic acid, 2-mercapto-5-nitro-, is used in the food industry as a preservative. Its ability to inhibit the growth of bacteria and fungi helps maintain the freshness and safety of various food products, extending their shelf life and preventing spoilage.

Upstream product

• 17302-46-4 methyl 2-hydroxy-5-nitrobenzoate 
• 1403384-97-3 2-dimethylcarbamoylsulfanyl-5-nitrobenzoic acid methyl ester 
• 1403384-95-1 2-dimethylthiocarbamoyloxy-5-nitrobenzoic acid methyl ester 
• 1170-38-3 2,2'-dithiobis[5-nitrobenzoic acid] 

Downstream Products

• 79003-36-4 α-[(2-carboxy-4-nitrophenyl)thio]-γ-butyrolactone 
• 198897-02-8 2-(2-Methylcarbamoyl-benzenesulfinyl)-5-nitro-benzoic acid 

Relevant academic research and scientific papers

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

We describe a set of benzisothiazolinone (BTZ) derivatives that are potent inhibitors of monoacylglycerol lipase (MGL), the primary degrading enzyme for the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Structure-activity relationship studies evaluated various substitutions on the nitrogen atom and the benzene ring of the BTZ nucleus. Optimized derivatives with nanomolar potency allowed us to investigate the mechanism of MGL inhibition. Site-directed mutagenesis and mass spectrometry experiments showed that BTZs interact in a covalent reversible manner with regulatory cysteines, Cys201 and Cys208, causing a reversible sulfenylation known to modulate MGL activity. Metadynamics simulations revealed that BTZ adducts favor a closed conformation of MGL that occludes substrate recruitment. The BTZ derivative 13 protected neuronal cells from oxidative stimuli and increased 2-AG levels in the mouse brain. The results identify Cys201 and Cys208 as key regulators of MGL function and point to the BTZ scaffold as a useful starting point for the discovery of allosteric MGL inhibitors.

Spiro-λ4-sulfanes with a N-SIV-O axial bond system. A kinetic study on the mechanism of hydrolysis

Kinetics of the hydrolysis of diaryl(acylamino)(acyloxy)spiro-λ4-sulfanes (2a-e, 3-5) leading to sulfoxides have been studied under pseudo-first-order conditions in dioxane-water mixtures or aqueous buffer solutions. A sulfonium-carboxylate-typ