99359-74-7Relevant academic research and scientific papers
Iridium-catalyzed regioselective silylation of aromatic and benzylic C-H bonds directed by a secondary amine
Li, Qian,Driess, Matthias,Hartwig, John F.
, p. 8471 - 8474 (2014)
Reported herein is an iridium-catalyzed, regioselective silylation of the aromatic C-H bonds of benzylamines and the benzylic C-H bonds of 2,N-dialkylanilines. In this process, (hydrido)silyl amines, generated in situ by dehydrogenative coupling of benzylamine or aniline with diethylsilane, undergo selective silylation at the C-H bond γ to the amino group. The products of this silylation are suitable for subsequent oxidation, halogenation, and cross-coupling reactions to deliver benzylamine and arylamine derivatives.
