99361-22-5Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents
Tang, Hui,Wu, Juan,Zhang, Wen,Zhao, Lei,Zhang, Ya-Hui,Shen, Cheng-Wu
, p. 1161 - 1164 (2015)
A series of 3-substituted quinazolinones, 2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in vitro. The new compounds revealed excellent in vitro antifungal activity with broad spectrum. The structure-activity relationships (SARs) of the derivatives were analyzed. Compound 9A2 exhibits better antifungal activity against 5 tested fungi in vitro than fluconazole, especially against Trichophyton rubrum and Microsporum gypseum. This study provides a series of novel lead compounds for the development of non-azole antifungal agents.
