99429-06-8 Usage
Chemical structure
heterocyclic aromatic compound with a pyrimidine ring
Substituents
fluorine atoms at the 2 and 5 positions, chlorine atom at the 4 position
Uses
building block in pharmaceutical synthesis, intermediate in agrochemical production, used in the synthesis of biologically active molecules
Versatility
valuable chemical with multiple applications in drug discovery and chemical synthesis
Check Digit Verification of cas no
The CAS Registry Mumber 99429-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,4,2 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 99429-06:
(7*9)+(6*9)+(5*4)+(4*2)+(3*9)+(2*0)+(1*6)=178
178 % 10 = 8
So 99429-06-8 is a valid CAS Registry Number.
99429-06-8Relevant articles and documents
A NEW ROUTE TO THE SYNTHESIS OF 5-FLUOROURACIL
Baasner, B.,Klauke, E.
, p. 417 - 430 (2007/10/02)
Starting from tetrafluoropyrimidine (1), selective fluorine/chlorine exchange reactions and selective hydrogenolysis of the chlorine substituents are described.Combination of these methods, together with a subsequent hydrolysis reaction, provides a new route to the synthesis of 5-fluorouracil via 4,6-dichloro-2,5-difluoropyrimidine and 4-chloro-2,5-difluoropyrimidine.
Process for the preparation of 5-fluorocytosine
-
, (2008/06/13)
5-fluorocytosine is prepared by reacting 2,5-difluoro-4-chloro-pyrimidine with a proton acid in the presence of water to yield 2-hydroxy-4-chloro-5-fluoropyrimidine and reacting the 2-hydroxy-4-chloro-5-fluoropyrimidine with ammonia to yield 5-fluoro-cytosine.
