99430-05-4

Basic information

• Product Name: 1-(2-hydroxy-5-methoxyphenyl)-3-phenyl-1-propanone
• Synonyms: 1-(2-hydroxy-5-methoxyphenyl)-3-phenyl-1-propanone
• CAS NO: 99430-05-4
• Molecular Weight: 256.301
• Mol File: 99430-05-4.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxy-5-methoxyphenyl)-3-phenyl-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxy-5-methoxyphenyl)-3-phenyl-1-propanone(99430-05-4)
• EPA Substance Registry System: 1-(2-hydroxy-5-methoxyphenyl)-3-phenyl-1-propanone(99430-05-4)

Safety Data

• Hazardous Substances Data: 99430-05-4(Hazardous Substances Data)

Upstream product

• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 100-51-6 benzyl alcohol 
• 645-45-4 hydrocinnamic acid chloride 
• 150-76-5 4-methoxy-phenol 
• 23522-71-6 4-methoxyphenyl 3-phenylpropanoate 

Downstream Products

• 26964-24-9 6-methoxyflavone 
• 3034-04-6 6-methoxyflavanone 

Relevant articles and documents

Synthesis and structural characterization of facile ruthenium(II) hydrazone complexes: Efficient catalysts in α-alkylation of ketones with primary alcohols via hydrogen auto transfer

As a immersion for development of new complexes, new Ru(II) complexes (1–3) supported by benzothiazole hydrazine Schiff bases of the type [Ru(SAL-HBT)(CO)(AsPh3)2], [Ru(VAN-HBT)(CO)(AsPh3)2] and [Ru(NAP-HBT)(CO)Cl(AsPh3)2] [SAL-HBT = (salicyl((2-(benzothiazol-2yl)hydrazono)methylphenol)), VAN-HBT = 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) and NAP-HBT = naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol)] were synthesized. Their identities have been established by satisfactory elemental analyses, various spectroscopic techniques (IR, (1H, 13C) NMR) and also mass spectrometry. The ruthenium(II) ion exhibits a hexa coordination with distorted octahedral geometry. In complexes 1 and 2, the ligand coordinated as dianionic tridentate fashion by forming N^N donor five member and N^O donor six member chelate rings. However, in complex 3, the ligand coordinated as monoanionic bidentate fashion by forming N^N donor five-membered ring. The new ruthenium(II) carbonyl complexes were successfully applied as catalysts in α -alkylation of aliphatic and aromatic ketones with alcohols via borrowing hydrogen strategy. Various parameters such as base, solvent, temperature, time and catalyst loading on the catalytic activity were analyzed. From the results, the catalyst 1 was found to be the best catalyst for α-alkylation reaction to obtain excellent yield. The catalytic system has a broad substrate scope, which allows the synthesis of α-alkylated ketones in mild reaction conditions with low catalyst loading under air atmosphere.

APPLICATION OF THE PHOTO-FRIES REARRANGEMENT OF ARYL DIHYDROCINNAMATES TO THE SYNTHESIS OF FLAVONOIDS

The photo-Fries rearrangement of aryl dihydrocinnamates is compared with that of the analogous cinnamates from a preparative point of view.The former proceeds with higher conversions, giving the corresponding 2'-hydroxydihydrochalcones in acceptable yields.This process, combined with well established reactions, provides an alternative entry to the synthesis of flavonoids.