99463-50-0

Upstream product

• 99463-49-7 (2S,3S)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 99463-49-7 (2S,3R)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 99463-49-7 (2R,3S)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 99463-49-7 (2R,3R)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 96323-55-6 (2R,3R)-2-((2R,4S,5S)-4-Benzo[1,3]dioxol-5-yl-2-phenyl-[1,3]dioxan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN.

A novel approach to (+/-)-epipodophyllotoxin (2) and hence also (+/-)-podophyllotoxin (1) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 14a to the tetralin derivative 15 with mesyl chloride.