99500-31-9Relevant academic research and scientific papers
Substituted alkylidene imidazoles
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, (2008/06/13)
This disclosure relates to a class of novel substituted alkylidene imidazole derivatives and pharmaceutically acceptable salts thereof. The disclosure further describes pharmaceutical compositions containing such compounds and to the use of such compounds
Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (±)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4 methoxyphenyl)-methoxy]methyl]ethoxy]hexanoic acids
Manley,Tuffin,Allanson,Buckle,Lad,Lai,Lunt,Porter,Wade
, p. 1812 - 1818 (2007/10/02)
A series of substituted ω-[2-(1H-imidazol-1-yl)ethoxy]alkanoic acid derivatives were synthesized and evaluated for their ability to inhibit thromboxane synthase both in vitro and in vivo. Compound 13 was identified as a potent and selective competitive in
