99512-10-4

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 3-amino-4-nitro-, is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, Benzonitrile, 3-amino-4-nitro-, is employed as an intermediate for the production of various dyes. Its chemical properties make it suitable for the creation of a wide range of colorants used in different applications, including textiles, plastics, and printing inks.
Used in Agrochemical Industry:
Benzonitrile, 3-amino-4-nitro-, is also utilized in the agrochemical sector as an intermediate for the synthesis of various agrochemicals. Its role in the production of pesticides, herbicides, and other agricultural chemicals helps to improve crop protection and yield.

Upstream product

• 17162-41-3 2,4,6-trichlorosulfenamide 
• 619-72-7 4-nitrobenzonitrile 
• 36389-13-6 5-benzofuroxancarbonitrile 
• 1635-61-6 5-chloro-2-nitroaniline 
• 5228-61-5 5-bromo-2-nitroaniline 
• 557-21-1 dicyanozinc 

Downstream Products

• 952184-79-1 3-[4-((S)-2-Methoxy-1-methyl-ethylamino)-pyrimidin-2-ylamino]-4-nitro-benzonitrile 
• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 453537-55-8 3-iodo-4-nitrobenzonitrile 

Relevant academic research and scientific papers

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO22+)

Benzofuroxans are interesting compounds which display several biochemical and pharmacological properties. Recent studies from our laboratory demonstrate that they are reduced by ferrous salts at room temperature and that the principal reaction products are o-nitroanilines. This paper shows that simple benzofuroxan derivatives are also able to oxidise HbO22+ to methemoglobin (MetHb3+) (UV detection) and to form o-nitroanilines (HPLC detection). From a toxicological point of view this reaction is interesting, since it indicates that the blood is a site for metabolism of these compounds with consequent methemoglobinemia and formation of toxic compounds.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.