99558-01-7

Upstream product

• 99558-00-6 4'-<3-(4-methylpiperazin-1-yl)propoxy>acetanilide 
• 109-01-3 1-methyl-piperazine 
• 402948-25-8 4-(3-Bromopropoxy)-2-nitrophenylamine 
• 13094-50-3 1-(3-bromopropoxy)-4-nitrobenzene 
• 220822-26-4 4-<3-(4-methylpiperazin-1-yl)propoxy>aniline 
• 99557-99-0 4-<3-(4-methylpiperazin-1-yl)propoxy>nitrobenzene 

Downstream Products

• 99558-02-8 4-<3-(4-methylpiperazin-1-yl)propoxy>-2-nitroiodobenzene 
• 1018895-66-3 4-(3-(4-methylpiperazin-1-yl)propoxy)benzene-1,2-diamine 
• 99562-27-3 Diethyl-(2-{4-[3-(4-methyl-piperazin-1-yl)-propoxy]-2-nitro-phenylethynyl}-benzyl)-amine 

Relevant academic research and scientific papers

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention

11H-Isoindoloindol-11-ones: Novel Rearrangement Products from the Attempted Preparation of 2-(2-Diethylaminomethylphenyl)isatogens

The attempted synthesis of 2-(2-diethylaminomethylphenyl)isatogens, from appropriately substituted phenylacetylenes and aromatic iodo compounds by two different routes gave novel substituted 11H-isoindoloindol-11-ones (6a-d) as the only identifiabl