99558-23-3Relevant academic research and scientific papers
Synthesis and oxidative rearrangement of selenenylated dihydropyrans
Redon, Sebastien,Pannecoucke, Xavier,Franck, Xavier,Outurquin, Francis
, p. 1260 - 1267 (2008)
Selenenylated dihydropyrans prepared by inverse demand hetero-Diels-Alder reactions undergo oxidative rearrangement when treated with H2O 2, leading to tetrahydrofuran-2-ones by ring contraction. The Royal Society of Chemistry.
COMPOUNDS FOR THE TREATMENT OF HIV
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Page/Page column 248; 249, (2013/03/26)
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
PREPARATION AND SOME REACTIONS OF 4- AND 5-ARYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONES
Breukelman, Stephen P.,Meakins, G. Denis
, p. 1627 - 1636 (2007/10/02)
Efficient preparations of 4- and 5-phenyl-4,5-dihydropyridazin-3(2H)-ones have been developed, the main reactions of these compounds have been studied, and the synthetic routes have been used to give analogues with substituents in the phenyl rings.In the best synthesis of the 4-phenyldihyropyridazinone (72 percent overall yield) the product was obtained from phenylacetic acid by three simple stages.This approach was applied in preparations of the 2- and 4-hydroxyphenyl compounds and, in conjunction with a recent method for amine protection, the 4-aminophenyl analogue.A four stage synthesis starting from benzaldehyde gave the 5-phenyldihydropyridazinone in 47 percent overall yield; hydroxybenzaldehydes were similarly converted into 5-(allyloxyphenyl)dihydropyridazinones.Oxidation to phenylpyridazinones occured more readily with the 4- and 5-phenyldihydropyridazinones than with the 6-phenyl isomer.The 4- and 5-dihydropyridazinones were smoothly reduced to tetrahydropyridazinones by hydrogenation over platinum but were uneffected by palladium in the presence of hydrazine or cyclohexene.
