99572-22-2 Usage
Description
(4R,4aβ,7aα,11aβ,14aα)-4β,11β-Dihydroxy-6aα,13aα-di(methylthio)-4,4a,6a,7,11,11a,14,14a-octahydro-1H,6H-pyrazino[1,2-a:4,5-a']diindole-1,6,8,13(7aH,13aH)-tetrone is a complex organic molecule with a tetrone structure. It is characterized by the presence of multiple hydroxy and methylthio groups, as well as a bicyclic ring system. This molecule has potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activity. Further research is needed to fully understand its properties and potential uses in various fields.
Uses
Used in Pharmaceutical Industry:
(4R,4aβ,7aα,11aβ,14aα)-4β,11β-Dihydroxy-6aα,13aα-di(methylthio)-4,4a,6a,7,11,11a,14,14a-octahydro-1H,6H-pyrazino[1,2-a:4,5-a']diindole-1,6,8,13(7aH,13aH)-tetrone is used as a potential pharmaceutical candidate for [application reason] due to its unique structure and potential biological activity.
Used in Drug Development:
In the field of drug development, (4R,4aβ,7aα,11aβ,14aα)-4β,11β-Dihydroxy-6aα,13aα-di(methylthio)-4,4a,6a,7,11,11a,14,14a-octahydro-1H,6H-pyrazino[1,2-a:4,5-a']diindole-1,6,8,13(7aH,13aH)-tetrone is used as a starting material or a structural component for the design of new drugs targeting various diseases, leveraging its unique chemical properties and potential interactions with biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 99572-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,5,7 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 99572-22:
(7*9)+(6*9)+(5*5)+(4*7)+(3*2)+(2*2)+(1*2)=182
182 % 10 = 2
So 99572-22-2 is a valid CAS Registry Number.
99572-22-2Relevant articles and documents
Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: Synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8′-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents
Nicolaou, K. C.,Lu, Min,Totokotsopoulos, Sotirios,Heretsch, Philipp,Giguere, Denis,Sun, Ya-Ping,Sarlah, David,Nguyen, Thu H.,Wolf, Ian C.,Smee, Donald F.,Day, Craig W.,Bopp, Selina,Winzeler, Elizabeth A.
, p. 17320 - 17332,13 (2020/09/02)
An improved sulfenylation method for the preparation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines from diketopiperazines has been developed. Employing NaHMDS and related bases and elemental sulfur or bis[bis(trimethylsilyl)amino]trisulfide (23) in THF, the developed method was applied to the synthesis of a series of natural and designed molecules, including epicoccin G (1), 8,8′-epi-ent-rostratin B (2), gliotoxin (3), gliotoxin G (4), emethallicin E (5), and haematocin (6). Biological screening of selected synthesized compounds led to the discovery of a number of nanomolar antipoliovirus agents (i.e., 46, 2,2′-epi-46, and 61) and several low-micromolar anti-Plasmodium falciparum lead compounds (i.e., 46, 2,2′-epi-46, 58, 61, and 1).
