99590-22-4Relevant academic research and scientific papers
TRIAZOLE MODIFIED COUMARIN AND BIPHENYL AMIDE-BASED HSP90 INHIBITORS
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Page/Page column 59-60, (2016/01/01)
Provided herein are compounds of the formulas:. which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including cancer, e
Triazole containing novobiocin and biphenyl amides as Hsp90 C-terminal inhibitors
Zhao, Jinbo,Zhao, Huiping,Hall, Jessica A.,Brown, Douglas,Brandes, Eileen,Bazzill, Joseph,Grogan, Patrick T.,Subramanian, Chitra,Vielhauer, George,Cohen, Mark S.,Blagg, Brian S. J.
supporting information, p. 1317 - 1323 (2014/10/15)
Hsp90 C-terminal inhibitors are advantageous for the development of new cancer chemotherapeutics due to their ability to segregate client protein degradation from induction of the prosurvival heat shock response, which is a major detriment associated with
1-(4-Substituted-benzyl)-1,2,3-triazoles, in vitro inhibitors of prostaglandin synthesis
Biagi,Livi,Lucacchini
, p. 267 - 271 (2007/10/02)
This paper describes the preparation of some 1-(4-substituted-benzyl)-1,2,3-triazole derivatives from 4-nitrobenzyl azide by 1,3-dipolar cycloaddition, functional group conversion and nucleophilic substitution reactions. Evaluation of these compounds as i
