99613-07-7

Upstream product

• 5487-33-2 O-benzylhomoisovanillic acid 
• 78792-73-1 5-benzyloxy-4-methoxy-2-nitrophenylacetic acid 

Downstream Products

• 79832-21-6 1-(2-amino-5-benzyloxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methylisoquinoline 
• 79832-12-5 1-(5-benzyloxy-4-methoxy-2-nitrobenzyl)-3,4-dihydro-6,7,8-trimethoxyisoquinoline 
• 549-28-0 protostephanine 
• 20824-18-4 protostephanone 
• 79831-92-8 5-benzyloxy-4-methoxy-2-nitro-N-(3,4,5-trimethoxyphenethyl)phenylacetamide 

Relevant academic research and scientific papers

Synthesis of (+/-)-12-Nitro and (+/-)-12-Amino Derivatives of Scoulerine, Coreximine, Tetrahydropalmatrubine and Xylopinine

(+/-)-12-Nitro derivatives of scoulerine, coreximine, tetrahydropalmatrubine, tetrahydropalimatine and xylopinine have been synthesized by Mannich condensation of suitably substituted 1-benzyltetrahydroisoquinolines with formaldehyde.Catalytic (10percent

Synthesis along Biosynthetic Pathways. Part 2. Synthesis of Protostephanine

The dienone protostephanone (3) is synthesised by phenol coupling or by Pschorr cyclisation from readily prepared tetrahydroisoquinolines, and the corresponding dienols (17) and (18) are converted by rearrangement, fragmentation, and reduction into protostephanine (4).This sequence mimics the natural pathway to the alkaloid.