99613-63-5

Basic information

• Product Name: 1-(azidomethyl)-3,4-dichlorobenzene
• Synonyms: 1-(azidomethyl)-3,4-dichlorobenzene
• CAS NO: 99613-63-5
• Molecular Formula: C₇H₅Cl₂N₃
• Molecular Weight: 202.0407
• Mol File: 99613-63-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(azidomethyl)-3,4-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(azidomethyl)-3,4-dichlorobenzene(99613-63-5)
• EPA Substance Registry System: 1-(azidomethyl)-3,4-dichlorobenzene(99613-63-5)

Safety Data

• Hazardous Substances Data: 99613-63-5(Hazardous Substances Data)

Usage

Uses

4-(azidomethyl)-1,2-dichlorobenzene is used as a reactant in the preparation of triazole-dithiocarbamate for antitumor activity.

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 1805-32-9 3,4-dichlorobenzyl alcohol 
• 18880-04-1 3,4-dichlorobenzyl bromide 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 

Downstream Products

• 1111881-51-6 ethyl 1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylate 
• 1111881-55-0 methyl 1-[(3,4-dichlorophenyl)methyl]-5-ethyl-1H-1,2,3-triazole-4-carboxylate 
• 1245773-37-8 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 
• 1617536-31-8 tert-butyl 2-(4-acetylpiperazin-1-yl)ethyl(1-(3,4-dichlorobenzyl)-1H-1,2,3-triazol-4-yl)carbamate 
• 1151240-85-5 {1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl}methanol 

Relevant articles and documents

Anti-Lung Cancer Activities of 1,2,3-Triazole Curcumin Derivatives via Regulation of the MAPK/NF-κB/STAT3 Signaling Pathways

In this study, a series of curcumin derivatives containing 1,2,3-triazole were designed and synthesized, and their inhibitory activities against the proliferation of lung cancer cells were studied. Compound 5 k (3,4-dichlorobenzyltriazole methyl curcumin)

P-benzoquinone diazide core skeleton derivative as well as preparation method and application thereof

The invention relates to a p-benzoquinone diazide core skeleton derivative and a preparation method and application, thereof, belongs to. the field of organic chemistry, and can effectively treat-ovarian-ovarian cancer-carcinoma STAT3-ovarian, cancer-ATG4

Synthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI-Fe3O4@SiO2 (TMS-EDTA)

In the present work, novel 5-((1-benzyl-1,2,3-triazol-4-yl)methoxybenzylidene)-2-(arylamino)thiazol-4-one thiazolone incorporated triazole derivatives have been designed as tyrosinase inhibitors. The compounds were synthesized through click reaction in good yield. Moreover, the antityrosinas activity of the synthesized derivatives was evaluated. In the search for establishing a click copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction under strict conditions, in terms of a novel air-stable, a recyclable and efficient magnetic catalyst was planned for new triazole derivatives as a well-organized copper iodide supported on the functionalized Fe3O4@SiO2 core-shell (CuI/Fe3O4@SiO2(TMS-EDTA) nanoparticles). The engineered nanocatalyst synthesized for the first time and characterized by different methods, including FT-IR spectroscopy, XRD, FESEM, EDX, TEM, TGA, and BET analysis. The excellent catalytic performance in ethanol with high surface area (351.7 m2g?1) and short reaction time for diverse functional groups (120–200 min), no use of toxic solvents, reusability of the catalyst, and using eco-friendly conditions are the advantageous of this work. Moreover,the nanocatalyst can be used at least five times without any significant decrease in the yield of the reaction. The thiazolidine-triazole derivatives 9a, 9c, 9e, and 9 g showed promising tyrosinase inhibitory activity with IC50 values in the range of 5.90–9.81 μM. The compounds were found to be considerably more potent tyrosinase inhibitors than the reference inhibitor kojic acid (IC50 = 18.36 μM).