99615-74-4Relevant academic research and scientific papers
Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues
Anindya, Roy,Jena, Tapan Kumar,Karamathulla, Shaik,Khadake, Shivaji Narayan,Khan, Faiz Ahmed,Monisha, Mohan,Tuti, Nikhil Kumar
, (2021/03/15)
Marine sponges of the genus Suberea produce variety of brominated tyrosine alkaloids which display diverse range of biological activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biologicall
Preparation of tetrazole-fused π-conjugated molecules and their fluorescence behavior
Hata, Takeshi,Hayashi, Yoshiki,Hasegawa, Yuki,Iwai, Masaaki,Ishii,, Ayumi,Hasegawa, Miki,Shigeta, Masayuki,Urabe, Hirokazu
supporting information, p. 662 - 665 (2019/07/12)
New tetrazole-fused π-conjugated molecules were prepared from dibromobenzonitriles by repeated regioselective Sonogashira-Hagihara cross-coupling with acetylenes and intramolecular nucleophilic cyclizations. The conjugated tetracyclic compounds exhibited fluorescence with lifetimes of nanosecond order. From TD-DFT calculations, excited state wavefunctions of compounds indicated that the HOMO-1→LUMO and HOMO→LUMO+1 mainly became the first excited state (S0→S1) to contribute significantly to light emission.
Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation
Ohe, Tomoyuki,Umezawa, Ryutaro,Kitagawara, Yumina,Yasuda, Daisuke,Takahashi, Kyoko,Nakamura, Shigeo,Abe, Akiko,Sekine, Shuichi,Ito, Kousei,Okunushi, Kentaro,Morio, Hanae,Furihata, Tomomi,Anzai, Naohiko,Mashino, Tadahiko
supporting information, p. 3708 - 3711 (2018/11/02)
We synthesized six novel BBR derivatives that were designed to avoid metabolic activation via ipso-substitution and evaluated for their degree of toxicity and hURAT1 inhibition. It was found that all of the derivatives demonstrate lower cytotoxicity in mouse hepatocytes and lower levels of metabolic activation than BBR, while maintaining their inhibitory activity toward the uric acid transporter. We propose that these derivatives could serve as effective uricosuric agents that have much better safety profiles than BBR.
N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis
Pham, Ngoc B.,Deydier, Sophie,Labaied, Mehdi,Monnerat, Severine,Stuart, Kenneth,Quinn, Ronald J.
, p. 541 - 551 (2014/03/21)
The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).
Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni
Ramirez Osuna, Moises,Aguirre, Gerardo,Somanathan, Ratnasamy,Molins, Elias
, p. 2261 - 2266 (2007/10/03)
Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.
Bromodecarbonylation and bromodecarboxylation of electron-rich benzaldehydes and benzoic acids with oxone and sodium bromide
Koo, Bon-Suk,Kim, Eun-Hoo,Lee, Kee-Jung
, p. 2275 - 2286 (2007/10/03)
Benzaldehydes and benzoic acids bearing ortho- and paraelectron donating substituents having unshared electron-pair have undergone bromodecarbonylation or bromodecarboxylation on treatment with sodium bromide in the presence of Oxone in aqueous methanol.
