99643-38-6

Usage

Uses

Used in Pharmaceutical Industry:
1,13,3,5,56,6-Octamethyl-2,2-spiro(2,3-dihydro-1H-benzimidazole) is used as an HSP90 inhibitor for its potential therapeutic applications in the treatment of cancer and other diseases. By targeting the heat shock protein 90, 1,13,3,5,56,6-Octamethyl-2,2-spiro(2,3-dihydro-1H-benzimidazole can disrupt the regulation of cell growth and survival, offering a promising approach for the development of targeted therapies.
Used in Medicinal Chemistry Research:
1,13,3,5,56,6-Octamethyl-2,2-spiro(2,3-dihydro-1H-benzimidazole) is used as a subject of interest in medicinal chemistry research for its unique structure and mechanism of action. Its ability to inhibit HSP90 makes it a valuable candidate for further development and exploration in the field, with potential applications in the discovery of new targeted therapies for various medical conditions.

Upstream product

• 75751-21-2 4,5-dimethyl-N,N'-dimethyl-o-phenylenediamine 
• 99643-47-7 2-chloro-1,3,5,6-tetramethylbenzimidazolium tetrafluoroborate 
• 3363-56-2 2,5,6-trimethylbenzimidazole 
• 99643-45-5 1,2,3,5,6-pentamethyl-1H-benzo[d]imidazol-3-ium iodide 

Relevant academic research and scientific papers

Electronic Structure of Heterospirenes-PE Spectroscopic Investigations

The synthesis of the heterospirenes 1-9 is described and their He I photoelectron (PE) spectra are recorded.The assignment of the first PE bands is based on a comparison with fragment molecules and on molecular orbital calculations using semiempirical methods (PPP, MINDO/3). in the case of 1, 2, 4, and 5 strong spirointeraction has been elucidated.For 3 the analysis of the spectrum is hampered due to the strong overlap of the bands while for 6 the nonplanarity brings about a reduction of spirointeractions.For 7-9 the interaction between both fragments could not be detected.