99646-81-8

Usage

Uses

Used in Fragrance and Flavor Industry:
Benzaldehyde, 2-amino-6-methylis used as a fragrance and flavoring agent for its aromatic properties. It contributes to the creation of various consumer products, such as perfumes, soaps, and food items, enhancing their sensory appeal and consumer experience.
Used in Pharmaceutical Industry:
Benzaldehyde, 2-amino-6-methylserves as an intermediate in the synthesis of various drugs. Its chemical structure allows it to be a building block in the development of new pharmaceuticals, potentially leading to the discovery of novel treatments and therapies.
Used in Research and Development:
Benzaldehyde, 2-amino-6-methylhas been studied for its potential health effects, including its role as a mutagen. This research is crucial for understanding the compound's impact on biological systems and its potential use in targeted therapies, such as cancer treatment.

Upstream product

• 54915-41-2 2-(hydroxymethyl)-3-methyl-1-nitrobenzene 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 61940-22-5 methyl 2-methyl-6-nitrobenzoate 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 65658-16-4 2-amino-6-methylbenzyl alcohol 

Relevant academic research and scientific papers

Easy Access to Quinolin-2(1 H)-ones via a One-Pot Tandem Oxa-Michael-Aldol Sequence

An efficient strategy for the synthesis of a variety of quinolin-2(1 H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2- quinolin-2(1 H)-one derivatives in good to excellent yields.

Metal free carboamination of internal alkynes - An easy access to polysubstituted quinolines

A metal free carboamination of unactivated alkynes towards highly substituted quinolines was realized in the presence of a synergistic Br?nsted acid catalyst system. Supported by mechanistic probes, the reaction proceeds via a highly reactive vinyl cation in a C-C bond formation - Schmidt reaction sequence. The irreversible extrusion of N2, as a powerful driving force, allows for a general conversion of poorly nucleophilic aliphatic alkynes.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF

This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also relates to pharmaceutical compositions containing such compounds.