99664-42-3Relevant academic research and scientific papers
Effect of UV-absorbing agents on photodegradation of tranilast in oily gels
Hori, Naohide,Fujii, Makiko,Ikegami, Kazuhiko,Momose, Den-Ichi,Saito, Noriyasu,Matsumoto, Mitsuo
, p. 1713 - 1716 (2007/10/03)
Tranilast (TL) oily gels containing UV-absorbing agents (UV absorber) were prepared; and the effect of the agents against photodegradation of TL was investigated. When 0.1% TL oily gel without UV absorber was exposed to light, TL was photochemically decom
Different Photodimerization Behaviour of Tranilast in α-, β- and γ-Cyclodextrin Complexes: Cavity-size and Stoichiometry Dependence
Utsuki, Tadanobu,Hirayama, Fumitoshi,Uekama, Kaneto
, p. 109 - 114 (2007/10/02)
The effects of α-, β- and γ-cyclodextrins (CDxs) on the photoisomerization and photodimerization of an antiallergic drug tranilast have been kinetically investigated. α- and β-CDxs decelerate both the photoisomerization and photodimerization of 1, showing saturation kinetics, due to 1:1 complex formation.On the other hand, γ-CDx accelerates the photodimerization of 1 at higher 1:γ-CDx molar ratios, but decelerates it at lower 1:γ-CDx molar ratios.The photoisomerization of 1 is decelerated over the γ-CDxconcentration range employed.The continuous variation plot of CDx-induced circular dichroism intensities of 1 and the solubility data indicate that 1 forms inclusion complexes with γ-CDx in different stoichiometry, depending on the guest:host molar ratio.At higher 1:γ-CDx molar ratios, 1 formed the 2:1 (guest:host) complex which accelerates by about 5500 times, the dimerization of 1.With increasing γ-CDx concentration, 1:1 and 1:2 complexes are formed and the dimerization rate of 1 decreases markedly; in particular, the 1:2 complex decelerates it by 19300 times.The results reveal clear evidence for the cavity-size- and stoichiometry-dependent dimerization of 1 in CDx complexes.
