99668-71-0Relevant articles and documents
Chitosan Immobilization on Bio-MOF Nanostructures: A Biocompatible pH-Responsive Nanocarrier for Doxorubicin Release on MCF-7 Cell Lines of Human Breast Cancer
Abazari, Reza,Mahjoub, Ali Reza,Ataei, Farangis,Morsali, Ali,Carpenter-Warren, Cameron L.,Mehdizadeh, Kayhan,Slawin, Alexandra M. Z.
, p. 13364 - 13379 (2018/10/31)
In this work, a bio-metal-organic framework (Bio-MOF) coated with a monodispersed layer of chitosan (CS; CS/Bio-MOF) was synthesized and applied as a pH-responsive and target-selective system for delivery of doxorubicin (DOX) in the treatment of breast cancer. The efficiency of the nanocarrier in loading and releasing DOX was assessed at different pH levels. To monitor the in vitro drug release behavior of the drug-loaded carrier, the carrier was immersed in a phosphate buffered saline solution (PBS, pH 7.4) at 37 °C. According to the observations, the nanocarrier presents a slow and continuous release profile as well as a noticeable drug loading capacity. In addition, the carrier demonstrates a pH-responsive and target-selective behavior by releasing a high amount of DOX at pH 6.8, which is indicative of tumor cells and inflamed tissues and releasing a substantially lower amount of DOX at higher pH values. In addition, the results indicated that pH is effective on DOX uptake by CS/Bio-MOF. A 3.6 mg amount of DOX was loaded into 10 mg of CS/Bio-MOF, resulting in a 21.7% removal at pH 7.4 and 93.0% at pH 6.8. The collapsing and swelling of the CS layers coated on the surface of the Bio-MOFs were found to be responsible for the observed pH dependence of DOX delivery. Moreover, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the trypan blue test were performed on the MCF-7 (breast cancer) cell line in the presence of the CS/Bio-MOF carrier to confirm its biological compatibility. In addition, Annexin V staining was conducted to evaluate the cytotoxicity of the free and loaded DOX molecules. On the basis of the obtained optical microscopy, MTT assay, fluorescence microscopy, and dyeing results, the CS/Bio-MOF carrier greatly enhances cellular uptake of the drug by the MCF-7 cells and, therefore, apoptosis of the cells due to its biocompatibility and pH-responsive behavior.
Structural insights into the usage of carboxylate ions as molecular pins
Swiatkowski, Marcin,Kruszynski, Rafal
, p. 265 - 277 (2017/08/10)
Two series of new isostructural coordination compounds containing cobalt, nickel, copper butyrates (butyr) or isobutyrates (ibutyr) and 1,10-phenanthroline (phen), of general formulas [M(phen)3]2+·2(butyr?)·11H2O and [M(phen)3]2+·2(ibutyr?)·14H2O, were synthesized in water solutions and characterized by X-ray crystallography, IR, UV–Vis and fluorescence spectroscopy, elemental and thermal analysis. The carboxylate anions are located in an outer coordination sphere, which is a unique phenomenon in case of ibutyr coordination compounds. The studied compounds exhibit layered packing in crystal net. The “aqueous layers” consist of water molecules and carboxylate groups of carboxylate anions, assembled via hydrogen bonds to the two dimensional supramolecular networks containing multiple different cyclic motifs. Coordination units together with aliphatic ends of carboxylate anions form the “coordination moieties layers”, which are internally connected via π?π and C–H?π intermolecular interactions. The carboxylate anions function as supramolecular linkers between these layers and allow pinning them together. The spectroscopic and thermal properties have been discussed and correlated with molecular structures of the studied compounds. Due to placement of carboxylate anions out of coordination moieties, the presented compounds can be ideal standards in spectroscopic determinations of coordination type of butyr and ibutyr ions in coordination compounds. The thermal analyses of the studied compounds revealed the possibility of formation of dihydrate forms, and such dihydrated compounds cannot be produced in direct synthesis performed in aqueous media. In properly set environment the studied compounds can be thermally converted to micro- and nanoparticles of respective metal oxides.
Carbon-Oxygen Bond Cleavage of Esters Promoted by Hydrido and Alkylcobalt(I) Complexes Having Triphenylphosphine Ligands. Isolation of an Insertion Intermediate and Molecular Structure of Phenoxotris(triphenylphosphine)cobalt(I)
Hayashi, Yoshinori,Yamamoto, Takakazu,Yamamoto, Akio,Komiya, Sanshiro,Kushi, Yoshihiko
, p. 385 - 391 (2007/10/02)
Carbon-oxygen bonds in aryl and alkyl carboxylates (R'COOR) are selectively cleaved by CoH(N2)(PPh3)3, and carboxylic esters R'COOCH2R' are formed by a Tischchenko type dimerization of aldehyde R'CHO, whereas the reaction of CoMe(PPh3)3 with the esters yields ketones R'COMe.The reaction products are accounted for by assuming insertion of the ester C=O double bond into the Co-H or Co-Me bond, followed by abstraction of the β-alkoxo group by cobalt.The intermediate (β-(ethoxy)alkoxo)cobalt(I) complex Co(OCH(CF3)OEt)(PPh3)3 has been isolated in the reaction of CoH(N2)(PPh3)3 with ethyl trifluoroacetate as well as by alcoholysis of CoH(N2)(PPh3)3 with CF3CH(OEt)OH.Treatment of CoH(N2)(PPh3)3 with phenyl acetate affords a tetrahedral phenoxocobalt(I) complex, Co(OPh)(PPh3)3.Crystals of the complex are monoclinic, space group P21/c, with a = 13.142(2) Angstroem, b = 19.661(3) Angstroem, c = 18.714(3) Angstroem, and β = 91.49(3) degree.Block-diagonal least-squares refinement leads to R = 0.075 and Rw = 0.081 for 2966 reflections.The molecular structure of the complexe consists of a tetrahedron with an O-bonded phenoxo group and three PPh3 ligands; the average Co-P distance is 2.320(4) Angstroem and Co-O 1.900(9) Angstroem, and the average P-Co-P angle is 109.9(1) degree, P-Co-O 109.1(4) degree, and Co-O-C 138.2(9) degree, respectively.
COORDINATION COMPOUNDS OF Co(II) WITH 2-METHYL- AND 1,2-DIZAMETHYLBENZIMIDAZOLE.
Slyusarenko,Artemenko,Lapina,Pokhodnya,Zakharenko
, p. 8 - 12 (2008/10/08)
The synthesis is described of new coordination compounds of Co(II) with 2-methylbenzimidazole and 1,2-dimethylbenzimidazole. Salts of cobalt(II) with organic acids (formic, acetic, propionic, butyric) were investigated. IR spectra, diffractograms, electronic spectra, and magnetic properties were investigated, on the basis of which conclusions were drawn concerning the structure of the materials.
