99687-03-3Relevant academic research and scientific papers
Synthetic approaches to 5:8-fused heterocyclic systems. A novel rearrangement during the synthesis of imidazo[4,5-e][1,2,4]triazocine ring system
Burnett,Hosmane
, p. 325 - 328 (1995)
The attempted ring-closure of 4-amino-1-benzyl-5-[(N2-benzyl-N2- methoxycarbonyl)hydrazinomethylenecarbonyl]imidazole (5b) in sodium hydride/dimethyl sulfoxide at 50-60 °C afforded 1,7-dibenzylxanthine (6) instead of the anticipated 5:8-fused heterocycle 4b. A tentative reaction pathway has been proposed for the observed transformation.
