99694-89-0

Upstream product

• 13720-58-6 1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone 
• 126570-31-8 2,5-Dimethyl-4-acetoxymethylacetophenone 
• 126570-30-7 2,5-Dimethoxy-4-bromomethylacetophenone 
• 24599-58-4 2,5-dimethoxy toluene 
• 126570-33-0 2,5-Dimethoxy-4-(2-hydroxyisopropyl)benzylalcohol 

Relevant academic research and scientific papers

Synthesis of Two Monoterpenic Hydroquinone Dimethyl Ethers Ocurring in Calea pilosa Baker

Two monoterpenic hydroquinone dimethyl ethers (1) and (2) have been synthesized starting from a common intermediate, 2,5-dimethoxy-4-methylacetophenone (4).Reaction of N-bromosuccinimide on 4 gives the bromomethyl compound (5) which is converted into the keto acetate (6) by exchange with OAc-.Grignard reaction with CH3MgI transforms 6 to 8 from which 1 is obtained by oxidative dehydration with MnO2.Compound (2) is obtained from 4 by the action of CH3MgI followed by dehydration with MnO2.