99713-70-9

Upstream product

• 99705-75-6 p-(2-methoxycarbonylethyl)phenyl 2,3,4-tri-O-acethyl-α-L-rhamnopyranoside 
• 69980-52-5 2,3,4-tri-O-acetyl-L-rhamnopyranosyl bromide 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 108-24-7 acetic anhydride 
• 99694-49-2 p-(2-methoxycarbonylethyl)phenyl 2,3-O-isopropylidene-4-O-(2,4,6-tri-O-acetyl-3-O-methyl-α-D-glucopyranosyl)-α-L-rhamnopyranoside 

Downstream Products

• 99694-39-0 p-(2-methoxycarbonylethyl)phenyl 2,3-di-O-methyl-4-O-(2,4-di-O-acethyl-3,6-di-O-methyl-α-D-glucopyranosyl)-α-L-rhamnopyranoside 

Relevant academic research and scientific papers

Synthesis of 3,6-di-O-Methylglucosyl Disaccharides with Methyl 3-(p-Hydroxyphenyl)propionate as a Linker Arm and Their Use in the Serodiagnosis of Leprosy

The disaccharide, 2,3-di-O-methyl-4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-L-rhamnopyranose, the distal segment of phenolic glycolipid I, that is a specific antigen from Mycobacterium leprae, and some related disaccherides were sythetised as the glycosides of methyl 3-(p-hydroxyphenyl)propionate.The methyl 3-(p-hydroxyphenyl)propionate was coupled with 2,3,4-tri-O-acetyl-L-rhamnosyl bromide, deacetylated, acetonated, coupled with 2,4,6-tri-O-acetyl-3-O-methyl-D-glucosyl bromide, and converted into a variety of p-(2-methoxycarbonylethyl)phenyl 4-O-(3,6-di-O-methyl-D-glucopyranosyl)-conataining disaccharides that are amenable to ready conjugation with protein carriers, therby providing neo-glycoconjugates for the specific serodiagnosis of leprosy.