99754-06-0 Usage
Uses
Used in Pharmaceutical Industry:
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID is used as a pharmaceutical agent for its potential therapeutic effects. Its unique chemical structure allows it to interact with specific biological targets, such as enzymes or receptors, modulating their activity and contributing to the treatment of various diseases.
Used in Chemical Research:
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID is utilized as a research compound in chemical and biological studies. Its unique structure and properties make it a valuable tool for understanding the mechanisms of action of various biological processes and for the development of new drugs and therapies.
Used in Drug Synthesis:
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID can be employed as a key intermediate in the synthesis of various pharmaceutical compounds. Its versatile chemical structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Material Science:
2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID may also find applications in material science, where its unique chemical properties can be exploited to develop new materials with specific characteristics, such as improved stability, enhanced reactivity, or tailored physical properties.
in vitro
previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].
References
1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197
2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361
3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530
4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004
5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507
Check Digit Verification of cas no
The CAS Registry Mumber 99754-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,7,5 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 99754-06:
(7*9)+(6*9)+(5*7)+(4*5)+(3*4)+(2*0)+(1*6)=190
190 % 10 = 0
So 99754-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H22ClNO3/c1-2-3-4-5-15-6-8-16(9-7-15)10-13-20(24)23-19-14-17(22)11-12-18(19)21(25)26/h6-14H,2-5H2,1H3,(H,23,24)(H,25,26)/b13-10+
