99755-86-9Relevant academic research and scientific papers
Action of Grignard Reagents and Amines on Some N-(Arylmethyleneamino)phthalimides
Ismail, M. Fekry,El-Bassiouny, F. A.,Enayat, E. I.,Kaddah, A. M.,Younes, H. A.
, p. 177 - 182 (2007/10/02)
N-(Arylmethyleneamino)phthalimides (2a-c) carrying an o-substituent in the aryl group were prepared by the reaction of N-aminophthalimide with o-substituted benzaldehydes.The reaction of these compounds with Grignard reagents proceeded either by normal addition to one of the carbonyl groups to give 3a-c or by addition and cleavage to give 4-arylphthalaz-1-ones 5a-c.The steric effect exhibited by either the Grignard reagent or the N-arylmethylene compound was studied.The reaction of N-furfurylideneaminophthalimide (2d) with Grignard reagents was also investigated.N-( Arylmethyleneamino)phthalimides reacted with primary amines to give N,N'-dialkylphthalamides (7a and b) while the reaction with secondary amines gave (8a and b).
