99763-40-3Relevant academic research and scientific papers
REACTION OF α-(3-INDOLYL)NITRONES WITH ARYL ISOCYANATES INCLUDING MIGRATION OF THE INDOLE RESIDUE
Velezheva, V. S.,Yaroslavskii, I. S.,Suvorov, N. N.
, p. 544 - 548 (2007/10/02)
When heated with aryl isocyanates, α-(3-indolyl)-N-aryl(alkyl)nitrones are converted into N-aryl-N'-aryl(alkyl)-N'-(3-indolyl)amidines.Subsequent hydrolysis of the N,N'-diphenyl-N'-(3-indolyl)amidine leads to 3-indolylformamide and 3-phenylaminoindole hydrochloride.When heated with acetic anhydride both with and without sodium acetate, the same nitrones are converted into the corresponding amides of 3-indolecarboxylic acid.The amide and ring nitrogen atoms are acylated simultaneously.N-Methyl-3-indolecarboxamide was obtained by the irradiation of α-(3-indolyl)-N-methylnitrone.
