99765-85-2Relevant academic research and scientific papers
Radical Cyclization of Alkene-Tethered Ketones Initiated by Hydrogen-Atom Transfer
Saladrigas, Mar,Bosch, Caroline,Saborit, Gisela V.,Bonjoch, Josep,Bradshaw, Ben
supporting information, p. 182 - 186 (2017/12/13)
An unprecedented C?C coupling reaction between alkenes and ketones by hydrogen-atom transfer, using Fe(acac)3 and PhSiH3 in EtOH, is described. This mild protocol features high site selectivity and allows the construction of sterically congested structures containing tertiary alcohols and quaternary centers. The overall process introduces a novel strategic bond disconnection for ring-closing reactions.
Addition of (Methylthio)methyl p-Tolyl Sulfone to α,β-Unsaturated Carbonyl Compounds
Ogura, Katsuyuki,Yahata, Nobuhiro,Minoguchi, Masanori,Ohtsuki, Kazuo,Takahashi, Kazumasa,Iida, Hirotada
, p. 508 - 512 (2007/10/02)
The lithio derivative of (methylthio)methyl p-tolyl sulfone (1) reacted with various α,β-unsaturated carbonyl compounds to afford adducts in good to high yields.The introduced (methylthio)(p-tolylsulfonyl)methyl group was easily converted to a (methylthio)carbonyl group or a formyl group.When the reaction of 1 with methyl acrylate using sodium hydride as a base was performed in DMF at an ambient temperature,2-(methoxycarbonyl)-4-(methylthio)-4-(p-tolylsulfonyl)cyclohexanone (8) was obtained in 81 percent yield.Furthermore, 8 was shown to be an important intermediate for preparing 2-substituted 2-(methoxycarbonyl)-1,4-cyclohexanediones.
