99805-40-0Relevant academic research and scientific papers
Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Br?nsted Base/H-Bonding Catalysis
Campano, Teresa E.,Iriarte, Igor,Olaizola, Olatz,Etxabe, Julen,Mielgo, Antonia,Ganboa, I?aki,Odriozola, José M.,García, Jesús M.,Oiarbide, Mikel,Palomo, Claudio
, p. 4390 - 4397 (2019)
Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Br?nsted base/H-bond catalysts to provide adducts with two consecutive tertiary stereocenters in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic molecules, including some with intricate carbon skeletons, was also demonstrated.
Palladium-catalyzed carbonylative coupling of (chloromethyl)arenes with terminal arylalkynes to produce 1,4-diaryl-3-butyn-2-ones
Feng, Xiujuan,Song, Jiliang,Liu, Hesong,Wang, Liangguang,Yu, Xiaoqiang,Bao, Ming
, p. 18985 - 18991 (2013/10/22)
A convenient and efficient method for the synthesis of 1,4-diaryl-3-butyn- 2-ones is described. The carbonylative coupling reactions of (chloromethyl)arenes with terminal arylalkynes proceeded smoothly in the presence of a PdCl2(PPh3)2 catalyst under mild reaction conditions to produce the corresponding 1,4-diaryl-3-butyn-2-ones in satisfactory to excellent yields. The Royal Society of Chemistry 2013.
Synthesis of spiro[4.5]trienones by intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes
Zhang, Xiaoxia,Larock, Richard C.
, p. 12230 - 12231 (2007/10/03)
A wide variety of 3-halospiro[4.5]trienones are readily prepared in good to excellent yields by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild reaction conditions. ICl, I2, and Br2 are all effective electrophiles for this process under carefully optimized reaction conditions. Copyright
