99808-74-9Relevant academic research and scientific papers
Synthesis of N-(Arylmethylene)dehydroalanine Methyl Esters and Their Application as Building Blocks in the Syntheses of Amino Acids
Wulff, Guenter,Boehnke, Helmut,Klinken, Heinz Theo
, p. 501 - 506 (2007/10/02)
Starting with serine, the useful N-(arylmethylene)dehydroalanine methyl esters 6 have been synthesized.These compounds react with nucleophiles in a Michael fashion to give the amino acid derivatives 8 and 9. - Hence, the Michael addition of diorganocopper (I) reagents as C nucleophiles to 6a yielding 9 provides a new method of amino acid synthesis.The extent of the desired 1,4 addition varies with the nature of the reagent and is dependent on several experimental parameters, viz: type of Cu (I) salt, complexing ligands, solvent, and temperature.
