99813-38-4Relevant academic research and scientific papers
Nano-Magnetic Sulfonic Acid Catalyzed Facile Synthesis of Diverse Amide Derivatives
Kothandapani, Jagatheeswaran,Ganesan, Asaithampi,Ganesan, Subramaniapillai Selva
, p. 685 - 692 (2017/01/25)
The excellent surface catalytic potential of Fe3O4-OSO3H is utilized in the synthesis of symmetrically and unsymmetrically substituted urea derivatives via transamidation reactions. The scope of the surface catalysis is further extended in transamidation reactions of cyclic and acyclic amide derivatives, and in the amidation of fatty acids. In both transamidation and amidation reactions, the catalyst is reusable up to five times without significant loss in its activity.
Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives
Narasimhan, Balasubramanian,Mourya, Vishnukant,Dhake, Avinash
, p. 3023 - 3029 (2008/09/20)
A series of esters and amides of myristic acid was synthesized and tested in vitro for antibacterial activity against Gram-positive and Gram-negative bacteria. All the compounds showed activity comparable to that of the standard drug, ciprofloxacin. The structural characteristics governing antibacterial activity of myristic acid derivatives was studied using QSAR methodology. The results showed that the antibacterial activity could be modeled using the topological descriptor, valence molecular connectivity index. The predictive ability of the models was cross-validated by construction of a test set. The low residual activity and high cross-validated r2 values ( rcv2 ) observed indicated the predictive ability of the developed QSAR models.
