99815-16-4

Basic information

• Product Name: 3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde
• Synonyms: 3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde;3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzaldehyde
• CAS NO: 99815-16-4
• Molecular Formula: C₁₉H₃₄O₃Si₂
• Molecular Weight: 366.64246
• Product Categories: Aromatics
• Mol File: 99815-16-4.mol
• Article Data: 41

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde(99815-16-4)
• EPA Substance Registry System: 3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde(99815-16-4)

Safety Data

• Hazardous Substances Data: 99815-16-4(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

3,4-Bis(tert-butyldiMethylsilyloxy)benzaldehyde is a reactant used in the preparation of dihydroxy stilbene derivatives as PTP1B inhibitors.

Upstream product

• 121-33-5 vanillin 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 109032-32-8 {[4-(2,2-dibromovinyl)-1,2-phenylene]bis-(oxy)}bis(tert-butyldimethylsilane) 
• 914954-92-0 (+/-)-1-[(3',4'-bis-(tert-butyldimethylsilanoxy)phenyl)]prop-2-en-1-ol 
• 1049679-46-0 1,2-bis(tert-butyldimethylsilyloxy)-4-[2-(4-styrylphenyl)vinyl]benzene 
• 1443299-30-6 4,4'-((1E,3E,5E)-hexa-1,3,5-triene-1,6-diyl)dibenzene-1,2-diol 
• 1612146-50-5 (Z)-N⁶-(5-(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)pent-4-en-1-yl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 1612146-69-6 (Z)-4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pent-1-en-1-yl)benzene-1,2-diol 
• 1612146-49-2 (Z)-5-(3,4-bis((tert-butyldimethylsilyl)oxy)phenyl)pent-4-enal 

Relevant articles and documents

Demonstrating the role of anchoring functionality in interfacial electron transfer dynamics in the newly synthesized BODIPY-TiO2 nanostructure composite

New BODIPY derivatives (dyes 1 and 2) with either catechol or resorcinol functionality, respectively, for anchoring to nanostructured (NS) TiO2 surfaces were synthesized. Extended conjugation at one of the two pyrrole rings at the C3 position helped us to achieve the desired control in tuning the optical and redox properties of the BODIPY based dye molecules. Relative emission quantum yields (Φem1 = ～52 ± 2% and Φem2 = 54 ± 2%) were found to be much higher in a polar aprotic solvent (acetonitrile) and substantially lower for dye 1 in a polar protic solvent. Steady state optical absorption studies revealed the formation of a strong charge transfer complex between dye 1 and NS-TiO2, while this interaction was much weaker for dye 2. Transient absorption studies were carried out for 1/NS-TiO2 and 2/NS-TiO2 systems following excitation with a laser source of 400 nm to understand the charge transfer dynamics. The results of the transient absorption spectral studies helped us to elucidate the role of anchoring functionality in influencing the dynamics of interfacial electron transfer and charge recombination processes on an ultrafast timescale.

Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described. We are hereby reporting a series of novel 3-(pyrazol-4-yl) imidazolidine-2,4-diones as potent and selective TAS2R8 antagonists. In human sensory tests, S6821 and S7958, two of the most potent analogues from the series, demonstrated efficacy in blocking TAS2R8-mediated bitterness and were selected for development. Following data evaluation by expert panels of a number of national and multinational regulatory bodies, including the US, the EU, and Japan, S6821 and S7958 were approved as safe under conditions of intended use as bitter taste blockers.

Resveratrol derivative containing fluorine group, and preparation method and application

The invention belongs to the technical field of medicines and discloses a resveratrol derivative containing a fluorine group, and a preparation method and an application. The resveratrol derivative has the structural characteristics as shown in a general