99822-65-8

Upstream product

• 7148-01-8 methyl 4-(4-chlorophenyl)-4-oxobutanoate 

Downstream Products

• 1578230-26-8 (S)-methyl 4-(4-chlorophenyl)-2-(2,3-dioxoindolin-1-yl)-4-oxobutanoate 
• 1609986-11-9 methyl 4-(4-chlorophenyl)-2-(2,3-dioxoindolin-1-yl)-4-oxobutanoate 

Relevant academic research and scientific papers

Remote activation of the nucleophilicity of isatin

The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.

Synthesis of 3-benzoyl acrylates/acrylamides via Dehydrogenation of 3-benzoyl propionates/propionamides using IBX/p-TsOH

Dehydrogenation by IBX/p-TsOH is applied to the conversion of 3-benzoyl propionates/propionamides to 3-benzoyl acrylates/acrylamides in moderate to excellent yields. The reaction time for the dehydrogenation of 3-benzoyl propionamides was remarkably short