99840-22-9

Upstream product

• 6940-78-9 4-chlorobutyl bromide 
• 70384-51-9 Tris(3,6-dioxaheptyl)amine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 46124-27-0 S-(4-chlorobenzyl)isothiourea 
• 6258-66-8 (4-chlorophenyl)methanethiol 

Downstream Products

• 124879-88-5 (1R,2R)-2-(4-Chloro-phenyl)-1-oxo-hexahydro-1λ⁴-thiopyran-2-carbothioic acid methylamide 
• 124880-01-9 (+/-)-2-(4-chlorophenyl)tetrahydrothiopyran-1-oxide 
• 124880-13-3 (+/-)-4-chloro-1-[(4-chlorobutyl)sulphinylmethyl]benzene 

Relevant academic research and scientific papers

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.

Thioformamide derivatives

This invention relates to thioformamide derivatives of the formula: STR1 wherein R represents alkyl, Ar represents optionally substituted phenyl, Y represents an ethylene or methylene radical or a valency bond, and n represents 0 or 1, bioprecursors there