99840-91-2Relevant academic research and scientific papers
Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions
Sureshbabu, Popuri,Azeez, Sadaf,Chaudhary, Priyanka,Kandasamy, Jeyakumar
, p. 845 - 850 (2019)
A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.
Photochemical activities of n-nitroso carboxamides and sulfoximides and their application to DNA cleavage
Hwu, Jih Ru,Huang, Joseph Jen Tse,Tsai, Fu-Yuan,Tsay, Shwu-Chen,Hsu, Ming-Hua,Hwang, Kuo Chu,Horng, Jia-Cherng,Ho, Ja An Annie,Lin, Chun-Cheng
experimental part, p. 8742 - 8750 (2010/03/31)
N-Nitroso compounds containing benzene, fluorene or fluorenone rings were synthesized. Photolysis of these compounds with 312-nm UV light provided the NO species, the presence of which was corroborated by use of an EPR method and of 2phenyl-4,4,5,5-tetramethylimidazolin-loxyl 3-oxide (PTIO) as a trapping agent. During irradiation of N-methylN-nitroso-9-fluorenone carboxamide (14c) in the absence of PTIO, it underwent decomposition followed by re-combination to give the heterocyclic nitric oxide radical 15. Incorporation of intercalating moieties endowed the Nnitroso compounds with DNA-cleaving ability through single-strand scission upon UV irradiation in a phosphate buffer (pH 5.0-8.0) under aerobic conditions.
Reaction of amides with nitric oxide (NO)
Itoh, Takashi,Nagata, Kazuhiro,Matsuya, Yuji,Miyazaki, Michiko,Ohsawa, Akio
, p. 5017 - 5020 (2007/10/03)
Amides were allowed to react with nitric oxide in aprotic and non- ethereal solvents to give the corresponding N-nitroso derivatives. The reaction was accelerated by addition of oxygen. The solvent effect revealed that the reaction did not proceed in the presence of protic media.
