99843-94-4Relevant academic research and scientific papers
COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PAIN
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Page/Page column 37-39, (2019/08/26)
The invention relates to compounds, pyridine derivatives, and pharmaceutical 10 compositions containing same for use in the treatment of pain. It also relates to specific compounds, compositions comprising the same and uses thereof, in particular in the treatment of pain.
Metal-free C–H arylation of aminoheterocycles with arylhydrazines
Taniguchi, Toshihide,Imoto, Mitsutaka,Takeda, Motonori,Matsumoto, Fukashi,Nakai, Takeo,Mihara, Masatoshi,Mizuno, Takumi,Nomoto, Akihiro,Ogawa, Akiya
, p. 4132 - 4140 (2016/07/06)
A direct C–H arylation of aminoheterocycles with arylhydrazine hydrochlorides was developed. The reaction proceeds via a homolytic aromatic substitution mechanism involving aryl radicals as the intermediates. The new reaction takes place readily at room t
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
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Page/Page column 48, (2016/10/31)
The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
Reactivity of Some 3-Substituted Derivatives of 2,6-Dihalogenopyridines Towards Potassium Amide in Liquid Ammonia .
Streef, J. W.,Hertog, H. J. den,Plas, H. C. van der
, p. 985 - 991 (2007/10/02)
Reactions of 2,6-dichloro-3-phenyl-, 2,6-dibromo-3-phenyl-, 2,6-dichloro-3-dimethylamino- and 2,6-dibromo-3-dimethylaminopyridine with potassium amide in liquid ammonia were investigated.Whereas 2,6-dichloro-3-phenylpyridine yields 4-amino-2-benzylpyrimidine, from 2,6-dibromo-3-phenylpyridine as a product of a novel ring fission 2-amino-1-cyano-1-phenyl-but-1-en-3-yne was isolated, together with 4-amino-6-bromo-3-phenylpyridine and 2,6-diamino-3-phenylpyridine.It was shown that neither 2-amino-6-bromo-3-phenyl- nor 6-amino-2-bromo-3-phenylpyridine are intermediates in the formation of the 2,6-diamino derivative, as these bromo compounds are transformed in the basic medium into 1,3-dicyano-1-phenylpropene.From both 2,6-dichloro-3-dimethylamino- and 2,6-dibromo-3-dimethylaminopyridine mixtures are obtained from which only 2-amino-1-cyano-1-dimethylamino-but-1-en-3-yne and 4-amino-6-halogeno-3-dimethylaminopyridine were isolated.Mechanisms for the reactions studied are proposed, i.e. a SN(ANRORC) mechanism for the aminodebromination of 2,6-dibromo-3-phenylpyridine into the corresponding 2,6-diamino compound.
