99846-32-9Relevant articles and documents
New synthesis of harzialactone A via kinetic resolution using recombinant Fusarium proliferatum lactonase
Chen, Bing,Yin, Hai-Feng,Wang, Zhen-Sheng,Xu, Jian-He
, p. 237 - 240 (2010)
A new synthesis of harzialactone A together with its stereoisomers was achieved starting from phenyl acetone. The key step of this new route is the kinetic bioresolution of racemic cis- and trans-isomers by recombinant Escherichia coli JM109 cells expressing Fusarium proliferatum lactonase gene (reFPL). Harzialactone A was isolated in excellent ee (>99%), while moderate to good enantioselectivities (80% to >99% ee) were obtained for its isomers.