99898-84-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one is used as a building block for the synthesis of various pharmaceuticals targeting specific diseases and disorders. Its unique chemical structure allows for the development of drugs with novel mechanisms of action and therapeutic potential.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one is employed as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can lead to enhanced efficacy and selectivity in controlling pests and weeds.
Used in Chemical Research:
5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one is used as a research reagent in chemical studies. Its unique structure and potential biological activities make it a valuable tool for investigating new chemical reactions, synthesis pathways, and the development of novel compounds.
Used in Biological Research:
As a research reagent in biological studies, 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one is utilized to explore its potential biological activities and interactions with biological systems. This can lead to a better understanding of its therapeutic potential and the discovery of new applications in medicine and other fields.

Upstream product

• 57489-77-7 5,7-dichloropyrazolo[1,5-a]pyrimidine 
• 672323-32-9 pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione 

Relevant academic research and scientific papers

Pyrazolopyrimidine compound as an ATR kinase inhibitor

Disclosed is a compound of a general formula (I), which may be used for the treatment of ATR kinase-mediated diseases, for example, proliferative diseases such as cancer. Further disclosed are a preparation method for the compound of the general formula (I), a pharmaceutical composition, and use of the pharmaceutical composition for the treatment of ATR kinase-mediated diseases.

Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors

The initial focus on characterizing novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as DPP-4 inhibitors, led to a potent and selective inhibitor compound b2. This ligand exhibits potent in vitro DPP-4 inhibitory activity (IC50: 80 nM), while maintaining other key cellular parameters such as high selectivity, low cytotoxicity and good cell viability. Subsequent optimization of b2 based on docking analysis and structure-based drug design knowledge resulted in d1. Compound d1 has nearly 2-fold increase of inhibitory activity (IC50: 49 nM) and over 1000-fold selectivity against DPP-8 and DPP-9. Further in vivo IPGTT assays showed that compound b2 effectively reduce glucose excursion by 34% at the dose of 10 mg/kg in diabetic mice. Herein we report the optimization and design of a potent and highly selective series of pyrazolo[1,5-a]pyrimidin-7(4H)-one DPP-4 inhibitors.

Novel DPP-4 enzyme inhibitor as well as preparation and application thereof

The invention provides a novel dipeptidyl peptidase-4 (DPP-4) inhibitor as well as preparation and application thereof and particularly discloses two pyrazolo[1,5-A]pyridine(4H)-one and pyrazolo[1,5-a]pyridine derivatives represented by a formula A and a formula B (shown in the description), preparation methods of the derivatives and use of the derivatives as the DPP-4 inhibitor, wherein each group is defined as shown in the description. A compound provided by the invention presents an excellent inhibition effect to DPP-4 and is used for preparing a pharmaceutical composition for treating diseases such as diabetes mellitus.