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4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-6-methyl- (9CI) is a chemical compound with the molecular formula C6H7N3O. It belongs to the class of pyrrolo[2,3-d]pyrimidin-4-ones, which are heterocyclic compounds with a pyrrolo ring fused to a pyrimidine ring. This specific compound features a 1,7-dihydro structure, indicating the presence of two hydrogen atoms attached to the first and seventh carbon atoms, and a methyl group (-CH3) attached to the sixth carbon atom. The compound is an important intermediate in the synthesis of various biologically active molecules, such as nucleosides and nucleotides, which play crucial roles in cellular processes like DNA replication and energy metabolism. Its unique structure and properties make it a valuable compound for research and development in the fields of medicinal chemistry and drug discovery.

99898-85-8

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99898-85-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 99898-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,8,9 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 99898-85:
(7*9)+(6*9)+(5*8)+(4*9)+(3*8)+(2*8)+(1*5)=238
238 % 10 = 8
So 99898-85-8 is a valid CAS Registry Number.

99898-85-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methyl-1,7-dihydropyrrolo[2,3-d]pyrimidin-4-one

1.2 Other means of identification

Product number -
Other names 4-Hydroxy-6-methylpyrrolo<2,3-d>pyrimidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:99898-85-8 SDS

99898-85-8Downstream Products

99898-85-8Relevant academic research and scientific papers

Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma

Harrison, Bryce A.,Whitlock, N. Andrew,Voronkov, Michael V.,Almstead, Zheng Y.,Gu, Kun-Jian,Mabon, Ross,Gardyan, Michael,Hamman, Brian D.,Allen, Jason,Gopinathan, Suma,McKnight, Beth,Crist, Mike,Zhang, Yulian,Liu, Ying,Courtney, Lawrence F.,Key, Billie,Zhou, Julia,Patel, Nita,Yates, Phil W.,Liu, Qingyun,Wilson, Alan G. E.,Kimball, S. David,Crosson, Craig E.,Rice, Dennis S.,Rawlins, David B.

supporting information; experimental part, p. 6515 - 6518 (2010/03/31)

The discovery of a pyrrolopyrimidine class of LIM-kinase 2 (LIMK2) inhibitors is reported. These LIMK2 inhibitors show good potency in enzymatic and cellular assays and good selectivity against ROCK. After topical dosing to the eye in a steroid induced mouse model of ocular hypertension, the compounds reduce intraocular pressure to baseline levels. The compounds also increase outflow facility in a pig eye perfusion assay. These results suggest LIMK2 may be an effective target for treating ocular hypertension and associated glaucoma.

KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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Page/Page column 13, (2009/03/07)

Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use

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