99901-99-2Relevant academic research and scientific papers
Anodic Cyclizations, Seven-Membered Rings, and the Choice of Radical Cation vs. Radical Pathways
Perkins, Robert J.,Feng, Ruozhu,Lu, Qingquan,Moeller, Kevin D.
, p. 672 - 678 (2019/05/28)
While many steps in an oxidative cyclization reaction can be important, it is the cyclization step itself that plays the central role. If this step does not proceed well, then optimization of the rest of the sequence is futile. We report here that the key
Synthetic method of diarylmethanes
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Paragraph 0217; 0218; 0219; 0220; 0221, (2017/08/28)
The invention discloses a synthetic method of diarylmethanes. The method is characterized in that benzyl pseudohalide and aromatic boric acid are reacted in an organic solvent under alkaline condition. The method employs easily available raw materials, conversion is realized under effect of no transition metal catalysis, water-free and oxygen-free are not required, Lewis acid catalysis is not required, the method has wide substrate universality, and various substituted diarylmethanes can be synthesized by the method.
Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts
Wu, Guojiao,Xu, Shuai,Deng, Yifan,Wu, Chaoqiang,Zhao, Xia,Ji, Wenzhi,Zhang, Yan,Wang, Jianbo
, p. 8022 - 8030 (2016/11/19)
We report herein a transition-metal-free coupling reaction of arylboronic acids with benzyl halides and mesylates for the construction of C(sp2)[sbnd]C(sp3) bonds. A unique feature of this coupling reaction is the formation regioisomers in some cases. Mechanistic studies suggest that this reaction may proceed via an unprecedented Friedel–Crafts-type reaction pathway under base conditions with the assistance of boronic acid moiety.
Iminium Ion Mediated Cyclizations with 4-Aryl-1,4-dihydropyridines. Bridging with Thiophene and Furan
Hartman, George D.,Halczenko, Wasyl,Phillips, Brian T.
, p. 142 - 148 (2007/10/02)
Treatment of -, phenyl-, - and -1,4-dihydropyridines with aluminum chloride afforded products derived from intramolecular trapping of the dihydropyridine/iminium ion by the
