99902-70-2

Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Chlorophenoxy)nicotinonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drug candidates. Its unique structure allows for the creation of compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 6-(4-Chlorophenoxy)nicotinonitrile is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its reactive functional groups that can be further modified to achieve desired properties for crop protection.
Used in Research and Development:
6-(4-Chlorophenoxy)nicotinonitrile is employed as a starting material in research and development for the synthesis of new potential drug candidates. Its versatility in chemical reactions makes it a valuable component in exploring novel therapeutic agents and chemical entities.

InChI:InChI=1/C12H7ClN2O/c13-10-2-4-11(5-3-10)16-12-6-1-9(7-14)8-15-12/h1-6,8H

Upstream product

• 33252-28-7 6-chloronicotinonitrile 
• 106-48-9 4-chloro-phenol 
• 99902-72-4 5-cyano-2-phenoxypyridine 

Downstream Products

• 2005-08-5 4-chlorophenyl benzoate 
• 1593235-54-1 2-(p-cyanobenzyl)-5-pyridinecarbonitrile 
• 1593235-55-2 2-(4-pyridylmethyl)-5-pyridinecarbonitrile 
• 10168-31-7 2-oxo-[1(2H),2'-bipyridine]-5'-carbonitrile 

Relevant academic research and scientific papers

Design, Synthesis, and Structure-Activity Relationship of New Pyrimidinamine Derivatives Containing an Aryloxy Pyridine Moiety

The pyrimidinamine diflumetorim is an ideal template for the discovery of agrochemical lead compounds due to its unique mode of action, novel chemical structure, and lack of reported resistance. To develop a new pyrimidinamine fungicide effective against cucumber downy mildew (CDM), a series of new pyrimidinamine derivatives containing an aryloxy pyridine moiety were designed and synthesized by employing the recently reported intermediate derivatization method (IDM). The structures of all compounds were identified by 1H NMR, elemental analyses, HRMS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Compound 9 gave the best activity (EC50 = 0.19 mg/L), which is significantly better than the commercial fungicides diflumetorim, flumorph, and cyazofamid. The relationship between structure and fungicidal activity of the synthesized pyrimidinamines was explored. The study showed that compound 9 is a promising fungicide candidate for further development.

Thieme Chemistry Journals Awardees - Where Are They Now? Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Ethers Using Heteroaryl Exchange Reaction

Unsymmetric di(heteroaryl) ethers were synthesized by the rhodium-catalyzed heteroaryl exchange reaction of heteroaryl aryl ethers and heteroaryl esters at equilibrium. Diverse unsymmetric di(heteroaryl) ethers containing five- and six-membered heteroaren

Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines

Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Co