99902-96-2Relevant academic research and scientific papers
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development
Letavic, Michael A.,Aluisio, Leah,Atack, John R.,Bonaventure, Pascal,Carruthers, Nicholas I.,Dugovic, Christine,Everson, Anita,Feinstein, Mark A.,Fraser, Ian C.,Hoey, Kenway,Jiang, Xiaohui,Keith, John M.,Koudriakova, Tatiana,Leung, Perry,Lord, Brian,Lovenberg, Timothy W.,Ly, Kiev S.,Morton, Kirsten L.,Timothy Motley,Nepomuceno, Diane,Rizzolio, Michele,Rynberg, Raymond,Sepassi, Kia,Shelton, Jonathan
scheme or table, p. 4210 - 4214 (2010/09/04)
The pre-clinical characterization of novel aryloxypyridine amides that are histamine H3 receptor antagonists is described. These compounds are high affinity histamine H3 ligands that penetrate the CNS and occupy the histamine H3 receptor in rat brain. Several compounds were extensively profiled pre-clinically leading to the identification of two compounds suitable for nomination as development candidates.
SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
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Page/Page column 13-14, (2008/06/13)
Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines
Markley,Tong,Dulworth,Steward,Goralski,Johnston,Wood,Vinogradoff,Bargar
, p. 427 - 433 (2007/10/02)
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Co
